Roche breast cancer drug extends overall survival












ZURICH (Reuters) – Swiss pharma group Roche‘s drug Perjeta significantly extended the lives of women with an aggressive and incurable form of breast cancer compared to a placebo, according to new data from a late-stage study presented on Saturday.


The detailed data presented at the San Antonio Breast Cancer Symposium found that the risk of death was reduced by 34 percent in women treated with a combination treatment of the drugs Perjeta and Herceptin plus chemotherapy compared to women treated with Herceptin, chemotherapy and a placebo, Roche said.












Roche is hoping that the Perjeta combination will become the standard treatment for women with a form of cancer known as HER2-positive, which makes up about a quarter of all breast cancers and has no cure.


At the time of the analysis, median overall survival had not yet been reached in people receiving the Perjeta combination, as more than half of these people continued to survive, Roche said.


Median overall survival was more than three years for people who received Herceptin and chemotherapy, Roche said, adding no new safety signals had been observed in the phase III study.


“This treatment combination with Perjeta is the first to have significantly extended survival compared to Herceptin and chemotherapy in people with previously untreated HER2-positive metastatic breast cancer,” Roche’s Chief Medical Officer Hal Barron said in the statement.


Breast cancer is the most common cancer among women worldwide, with about 1.4 million new cases diagnosed each year and more than 450,000 women dying of the disease annually, according to the World Health Organisation.


Perjeta, also known as pertuzumab, is a personalized medicine that targets a protein found in high quantities on the outside of cancer cells in HER2-positive cancers.


It was granted approval by U.S. health regulators in June. Roche is awaiting a decision from European regulators.


Vontobel analyst Andrew Weiss forecasts peak sales of 2 billion Swiss francs ($ 2.15 billion) for the drug.


Roche is also developing an “armed antibody” known as TDM-1 as a treatment for HER2-positive breast cancer. TDM-1 combines Herceptin with a derivative of a powerful type of chemotherapy and is designed to reduce unpleasant side effects. ($ 1 = 0.9313 Swiss francs)


(Reporting by Silke Koltrowitz and Caroline Copley; Editing by Paul Tait)


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S.Africa’s rand firms with emerging market currencies












JOHANNESBURG (Reuters) – South Africa‘s rand firmed slightly against the dollar on Friday as positive U.S. jobs numbers boosted the currencies of several emerging market countries on the hopes they would benefit from a more buoyant American economy.


The rand was 0.29 percent firmer at 8.6577 against the dollar at 1619 GMT from New York’s Thursday close of 8.6850.












“The good jobs numbers fundamentally boosted the global mood, which immediately impacted U.S. equities for the better, and this benefitted the rand and other emerging currencies,” said Anisha Arora, emerging market analyst for London-based 4Cast.


The yield on the three year bond slid one basis point to 5.47 percent while the longer dated 14-year paper fell seven basis points to 7.435 percent.


The rand was expected to come under pressure ahead of a major meeting of the African National Congress from mid-December with investors worried debt could increase if the ruling party pushes for populist policies that drive up spending.


Data scheduled for release next week include retail sales and manufacturing production data for October. There will also be data on November consumer inflation and producer inflation.


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“Gangnam Style” singer Psy apologizes for past anti-U.S. songs












LOS ANGELES (Reuters) – The South Korean pop singer behind the viral smash hit “Gangnam Style” apologized on Friday for past concerts featuring anti-American lyrics, ahead of a holiday performance to be attended by U.S. President Barack Obama and his family.


Psy issued the apology after reports surfaced in the United States on Friday about his participation in two performances critical of the U.S. military in 2004.












Psy’s “Gangnam Style” Korean pop and dance video is now the most-watched video ever on YouTube, with more than 900 million views since it was first uploaded in July.


“While I’m grateful for the freedom to express one’s self, I’ve learned there are limits to what language is appropriate and I’m deeply sorry for how these lyrics could be interpreted,” the rapper said in a statement.


“I will forever be sorry for any pain I have caused by those words,” he added.


In one performance, which Psy said was from eight years ago, the rapper protested the deaths of two teenage South Korean girls who were run over by a U.S. tank stationed in the country.


In a separate performance, Psy was critical of the U.S.-led invasion of Iraq and its occupation, in which South Korean forces participated.


Psy is scheduled to perform at the annual “Christmas in Washington” television special that will also be attended by Obama and his family, the White House said on Friday. Broadcaster TNT said Psy would still perform as planned.


(Reporting by Eric Kelsey; Additional reporting by Mark Felsenthal in Washington; Editing by Jill Serjeant and Peter Cooney)


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Men more likely to die of cancer: study












(Reuters) – Not only are men more likely than women to be diagnosed with cancer, men who get it have a higher chance of dying from the disease, according to a U.S. study.


In an analysis of cases of all but sex-specific cancers such as prostate and ovarian cancer, for example, men were more likely than women to die in each of the past ten years, said researchers, whose findings appeared in The Journal of Urology.












That translates to an extra 24,130 men dying of cancer in 2012 because of their gender.


“This gap needs to be closed,” said Shahrokh Shariat from Weill Cornell Medical College in New York, who worked on the study. “It’s not about showing that men are only doing worse and, ‘poor men.’ It’s about closing gender differences and improving health care.”


Using U.S. cancer registry data from 2003 through 2012, Shariat and his colleagues found the ratio of deaths to cancer diagnoses decreased 10 percent over the past decade – but was consistently higher among men than women.


Overall, men with any type of cancer were six percent more likely to die of their disease than women with cancer. When men and women with the same type of cancer were compared, that rose to more than 12 percent.


In 2012, Shariat’s team calculated that about 575,130 men and 457,240 women would be diagnosed with a non-sex specific cancer. Also this year, an estimated 243,620 men will die of cancer – one death for every 2.36 new diagnoses, compared to 182,670 women dying, or one for each 2.5 new diagnoses.


“We found that from the 10 most common cancers in males and females… men present at a higher stage than females, and adjusted for the incidence, are more likely to die from the cancer,” Shariat told Reuters Health.


“If you take an average of the 10 most common cancers, men are more likely to die in seven out of the ten,” he added. In contrast, women are more likely to die only from bladder cancer.


The new study can’t show what’s behind the differences in cancer deaths, but possible theories include men’s higher rates of smoking and drinking combined with less frequent doctor’s visits – which cause men’s cancers to be diagnosed in later, more advanced stages.


Sex hormones may also contribute to differences in men’s and women’s immune systems, metabolism and general susceptibility to cancer, according to Yang Yang, a sociologist and cancer researcher from the University of North Carolina at Chapel Hill, who studies health disparities but wasn’t part of the study.


She said the new findings are consistent with work suggesting a higher risk of death for men from many causes, not just cancer.


But a full understanding of the origins and mechanisms in sex differences in cancer, as well as overall mortality, has remained elusive,” Yang told Reuters Health in an email.


Shariat said men should be particularly proactive about their health care.


“That means going to screening programs, seeing a general practitioner or primary care provider on a regular basis and as soon as symptoms arise that are new, mentioning that to their primary care physicians,” he added. SOURCE: http://bit.ly/Vz8RJI


(Reporting from New York by Genevra Pittman at Reuters Health, editing by Elaine Lies)


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Euro falls on grim economic outlook, U.S. data eyed












LONDON (Reuters) – The bleak outlook for the European economy knocked the euro and stalled gains the region’s share markets on Friday, as investors waited to see if nonfarm payrolls data in the United States might affect its monetary policy plans.


A day after the European Central Bank cut its forecasts for growth across the 17-nation euro area next year, Germany’s Bundesbank said there was a chance the region’s debt crisis could send Europe’s biggest economy into recession.












The euro dropped 0.25 percent to a low of $ 1.2932 after the Bundesbank statement, extending losses of over one percent seen on Thursday in reaction to the ECB‘s new forecasts which have heightened speculation of a early rate cut.


“It is unusual that a negative growth projection for the next year is offered before the end of the current year, but with such a view, markets are naturally pricing in an interest rate cut,” said Daisuke Karakama, market economist for Mizuho Corporate Bank.


The main March 2013 German government bond futures contract, which had rallied sharply on the talk of an early ECB rate, was about 3 ticks lower at 145.66, with traders cutting back positions ahead of the U.S. jobs data.


European shares were fractionally higher in early trading, but mainly consolidating around the 18-month highs reached on Thursday on hopes of an improving economic performance in the global economy.


The FTSEurofirst 300 index <.fteu3> of top European shares traded up 0.2 percent at 1,133.95 points, with Germany’s Dax <.gdaxi> up 0.1 percent after the Bundesbank’s announcement.</.gdaxi></.fteu3>


London’s FTSE 100 <.ftse>, and Paris’s CAC-40 <.fchi> opened flat to slightly higher, while a slight dip in U.S. stock futures hinted at a cautious Wall Street open. <.l><.eu><.n></.n></.eu></.l></.fchi></.ftse>


Investors are focused on U.S. non-farm payrolls data, which is expected to show an addition of 93,000 jobs in November, probably dented by superstorm Sandy, against October’s gain of 171,000. The figures, due at 1330 GMT, are also likely to show the unemployment rate holding steady at 7.9 percent.


Federal reserve policymakers are scheduled to meet Dec 11-12 to review monetary policy.


Brent crude meanwhile was steady above $ 107 per barrel, but prices were headed for their biggest weekly loss in more than a month on the worries about the euro zone’s economy and on-going concerns about the looming fiscal crisis in the United States, the world’s top oil consumer.


Brent rose 0.1 percent to $ 107.14. while U.S. crude futures inched up 0.2 percent to $ 86.41 a barrel.


(Reporting by Richard Hubbard; editing by Philippa Fletcher)


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AP Interview: Jackson, cast discuss ‘The Hobbit’












WELLINGTON, New Zealand (AP) — Many fans are eagerly anticipating a return to the fictional world of Middle-earth with next week’s general release of the first movie in “The Hobbit” trilogy. Director Peter Jackson and the film’s stars speak to The Associated Press about making “The Hobbit: An Unexpected Journey“:


— Jackson on shooting at 48 frames per second instead of the standard 24: “We’ve seen the arrival of iPhones and iPads and now there’s a generation of kids — the worry that I have is that they seem to think it’s OK to wait for the film to come out on DVD or be available for download. And I don’t want kids to see ‘The Hobbit‘ on their iPads, really. Not for the first time. So as a filmmaker, I feel the responsibility to say, ‘This is the technology we have now, and it’s different … How can we raise the bar? Why do we have to stick with 24 frames? …’”












“The world has to move on and change. And I want to get people back into the cinema. I want to play my little tiny role in encouraging that beautiful, magical, mysterious experience of going into a dark room full of strangers, and being transported into a piece of escapism.”


Martin Freeman (Bilbo Baggins) on shooting some scenes without other actors around: “I must admit I found the green screen and all that easier than I thought I would. … I found the technical aspect of it quite doable. Some of it’s difficult, but it’s quite enjoyable, actually. It taps into when I used to play ‘war’ as a 6-year-old. And the Germans were all imaginary. Because I was playing a British person. So yeah, I was on the right side. …”


On marrying his performance to that of Ian Holm, who played an older Bilbo Baggins in the “Lord of the Rings” trilogy: “I knew I couldn’t be a slave to it. Because as truly fantastic as Ian Holm is in everything, and certainly as Bilbo, I can’t just go and do an impression of Ian Holm for a year and a half. Because it’s my turn. But it was very useful for me to watch and listen to stuff he did, vocal ticks or physical ticks, that I can use but not feel hamstrung by.”


— Hugo Weaving (Elrond) on the differences in tone to the “Rings” trilogy: “This one feels lighter, more buoyant, but it’s got quite profoundly moving sequences in it, too … I think it’s very different in many ways, and yet it’s absolutely the same filmmaker, and you are inhabiting the same world.”


— Elijah Wood (Frodo) on returning to Middle-earth in a cameo role: “It was a gift to come back … what they’d constructed was such a beautiful remembrance of the characters from the original trilogy.”


Cate Blanchett (Galadriel) on the toughest part of filming: “Trying to keep my children off the set.”


Richard Armitage (Thorin Oakenshield) on being a 6-foot-2 guy playing a dwarf: “It’s amazing how quickly you get used to it. And also, we spent most of the shoot much bigger than a 6-foot-2 guy. I mean, I had lifts in my shoes, I was wider, I was taller, and bigger-haired. And I actually think that was quite an interesting place to be, because I do think dwarfs have big ideas about themselves …”


— Andy Serkis (Gollum) on taking on the additional role of second-unit director: “There were only a couple of times where there were really, really black days where I went away thinking, ‘This is it. I can’t do it.’ But on the whole, Pete (Jackson) was so brilliant at allowing me to set stuff up and then critiquing my work … but at least I would have my stab at it.”


On the film itself: “I think it’s a great story. I think it’s a beautifully crafted film with great heart. A rollicking adventure, and it feels to me like this really massive feast that everyone will enjoy eating.”


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South Africa military plane crashes in mountains












JOHANNESBURG (AP) — A South African military aircraft on an unknown mission to an area near the village where former President Nelson Mandela lives crashed in a mountain range, officials said Thursday. It was unclear whether there were any survivors.


The Douglas DC-3 Dakota, a twin-propeller aircraft, had taken off from Pretoria’s Waterkloof Air Force Base on Wednesday night, said Brig. Gen. Xolani Mabanga, a military spokesman. On Thursday morning, soldiers found the wreckage of the airplane in the Drakensberg mountains near Ladysmith in KwaZulu-Natal province, some 340 kilometers (210 miles) southeast of the air base, Mabanga said.












Mabanga said soldiers had been sent to the scene to look for survivors. Mabanga said he did not know what the mission of the aircraft was, though it had planned to land in Mthatha in the country’s Eastern Cape. Siphiwe Dlamini, a Defense Ministry spokesman, declined to immediately comment Thursday morning.


Mthatha is about 30 kilometers (17 miles) north of Qunu, the village where Mandela now lives after retiring from public life. South Africa‘s military remains largely responsible for the former president’s medical care. However, military officials declined to say whether those on board had any part in caring for Mandela.


In November, another South African military flight crash landed at Mthatha, sending several people to the hospital with injuries. However, at that time, the military denied that those on board had anything to do with Mandela’s care.


Mandela, 94, was imprisoned for nearly three decades for his fight against apartheid before becoming the nation’s president in the country’s first fully democratic vote in 1994.


___


Jon Gambrell can be reached at www.twitter.com/jongambrellAP .


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Sanctions, government blamed for Iran’s drugs shortage












DUBAI/ZURICH (Reuters) – Doctors in Iran are trying to fend off a creeping health care crisis caused by medicine shortages, due in part to Western economic sanctions but exacerbated by government mismanagement and abuse of the system.


Government hospitals and pharmacies report a widespread lack of drugs to treat cancer, multiple sclerosis, blood disorders and other serious conditions. Iranian media highlighted the shortages earlier this month through the case of a teenager who died of hemophilia after his family failed to find his medicine.












Both the United States and the European Union say their embargoes do not target trade in humanitarian goods. But cutting off Iran’s banking system from the outside world has touched every sector of the economy, resulting in spiraling food prices, a plunging Iranian rial, deepening unemployment and now, hitting health care, analysts and traders say.


Western officials appear increasingly sensitive to allegations the measures put the lives of Iranians in danger.


“There’s a serious shortage of cancer medicine. The lives of so many patients are at risk,” one cancer specialist said by phone from Tehran. A wide range of drugs was no longer available, he said, and finding alternatives was a complex challenge.


Last month Iranian media published a list of dozens of drugs in short supply, and others – including chemotherapy treatment drugs Doxorubicin, Fluorouracil and Cytarabine – which could no longer be found.


Health officials have accused the government of compounding the shortages by failing to provide billions of dollars of vital funds earmarked for drugs and medical supplies.


“Those who have relatives in the West can ask them to get pills but how are they going to pay for them when the rial has lost so much of its value to the dollar?” the doctor said.


Iran’s currency has depreciated by more than half since the beginning of the year, leaving most Iranians struggling to pay for basic goods, let alone expensive imported medications.


Ali, 68, has been treated for Alzheimer’s disease for the last four years. In recent weeks he has been unable to purchase the German-made drug he takes in Iran and is now waiting for his medication to be delivered from France, where his son lives.


“It’s really frustrating. It’ll be really difficult to pay for them. We’re talking expensive pills here,” he said by phone.


Ali’s insurance policy covers drugs bought in Iran but not abroad, and his bill was expected to run to hundreds of dollars.


SANCTIONS CRITICISM


The issue has sparked ferocious attacks on the United States and European Union sanctions from pharmacists, doctors and medical institutions inside Iran.


“The objective behind these illegal and inhumane sanctions is to apply pressure on the Iranian government by inflicting pain and misery upon ordinary people,” Dr Alireza Marandi, of Iran’s Academy of Medical Sciences, said in a recent letter to U.N. Secretary General Ban Ki-Moon.


“These brutal measures have … led to a significant rise in suffering as well as increased mortality rates.”


The United States denies it is to blame.


“It has been the longstanding policy of the United States not to target Iranian imports of humanitarian items, such as food, medicine and medical devices,” said a Treasury spokesman.


In October, the United States introduced a “standing authorization” that permitted U.S. companies to sell certain medicines and supplies without first seeking a license from the Treasury’s Office of Foreign Assets Control, he said.


“If there is in fact a shortage of some medicines in Iran, it is due to choices made by the Iranian government, not the U.S. government,” he said.


Both London and Washington have aimed to communicate such views to ordinary Iranians through social media and online forums in recent weeks, concerned that hardships caused by the sanctions are overshadowing their message about the dangers of Iran’s nuclear program.


Tehran’s plan to enrich uranium has fuelled Western fears the clerical leadership is intent on developing a nuclear weapons capability. Tehran says it only wants a domestic nuclear energy program.


A British government spokesperson said the situation was being “compounded by the Iranian government’s economic mismanagement”.


CURRENCY SHORTAGE


Critics inside Iran, and even within the government itself, have accused officials of negligence by launching costly economic reforms at a time of increasing uncertainty and reduced government revenues.


Facing a slump in the amount of foreign reserves caused by sanctions against its oil exports, analysts say there is a tug-of-war between factions over who can access Iran’s petro-dollars, and government departments are losing out.


The amount of foreign reserves held by Iran is not known, but analysts and diplomats say it could be as little as $ 40 billion, with around a third of that stuck in foreign accounts and therefore inaccessible.


Iran subsidizes the purchase of dollars at the rate of 12,260 rials to the dollar for importing essential items including medicine and basic food stuffs. The open market exchange rate is around 30,000 rials.


Last month, Minister of Health Marzieh Vahid Dastjerdi said only a quarter of the $ 2.4 billion earmarked for medicine imports had been provided for the current year and there was a deficit of foreign currency for shipments.


“Medicine is more essential than bread. I have heard that luxury cars have been imported with subsidized dollars but I don’t know what happened to the dollars that were supposed to be allocated for importing medicine,” she said on state television.


A source inside a government pharmacy in Tehran said that low stocks of vital drugs were being exacerbated by “strategic stockpiling”. Of 20 units of medication, two were available to the public and the rest “reserved” for those who have influence or good connections, said the source.


Some importers also complain they can no longer access the government’s subsidized dollar rate because some medicines have been taken off the priority list. Instead of struggling on, many businesses have decided to close down.


Last Friday Mohammad Abdzadeh, the director general for supervision of medicine, told Fars news agency that $ 130 million of shipments had begun and would be completed in two weeks.


“After these special shipments we will proceed normally with imports and I hope we will no longer see any further shortages like those of the last one or two months,” he said.


ALTERNATIVE TREATMENTS


Some have benefited from the crisis – there is a growing market in Iranian and Chinese alternatives to drugs in short supply, for example. But while Iran has trumpeted domestic production of medicines in a drive towards self-sufficiency, doctors and pharmacists say they are reluctant to use many of them.


“Doctors just don’t want to take the risks with local drugs. In some cases they are jeopardizing the health of patients,” said a Western businessman who exports pharmaceutical products to Iran and visits the country regularly.


“The price for imported medicines may be 10 times more but they’re still going to prescribe them if they can,” he said.


There have even been reports of unwanted pregnancies due to the shortage in effective contraceptives.


A brand of contraceptive manufactured by the German pharmaceutical giant Bayer which had been widely sold in pharmacies is now nowhere to be found, said Ahmad, who imported it until the volatile currency situation forced him to stop.


“There are now some birth-control pills in the market from China. They just don’t work,” he said, asking to be identified only by his first name.


“I’ve heard of several cases where women on those got pregnant. This is not a joke. It’s really serious.”


One Tehran resident said there was a shortage of Western-made condoms in Iran because they were now classified as a luxury product and no longer on the priority list.


“We are still able to buy Chinese brands (which are awfully bad),” the unmarried 30-year-old wrote in an e-mail, “but even those are twice the previous price.”


(Editing by Sonya Hepinstall)


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Standard Chartered sees $330 million settlement on Iran












HONG KONG (Reuters) – Standard Chartered expects to pay $ 330 million to settle a case with U.S. regulators who accused the Asia-focused bank of failing to comply with sanctions against Iran, further denting profit growth this year.


The settlement will be on top of the $ 340 million it paid to New York’s Department of Financial Services in the third quarter, which pushed its before-tax profit growth in 2012 to a mid-single-digit percentage from more than 10 percent, StanChart said in a statement on Thursday.












Any earnings growth would mean a 10th straight year of record profits, as StanChart has ridden on Asia‘s rise through much of the last decade, allowing it to continue hiring and increasing earnings when much of the industry is shrinking.


“It ain’t broke, so they’re not fixing it,” said Jim Antos, an analyst at Mizuho Securities in Hong Kong. “The thing they are doing is trying to add new businesses, but there isn’t a compelling story and that’s why their shares haven’t moved.”


Standard Chartered said it expected talks with U.S. Federal regulators to conclude shortly, confirming a Reuters report in early November.


Despite its regulatory woes, the bank is one of the few still hiring in the industry, saying in August it intended to add at least 1,500 more staff in the second half of this year. By contrast, most rivals have been cutting, with Citi saying on Wednesday it was cutting 11,000 jobs.


“We continue to see significant opportunities across our markets in Asia, Africa and the Middle East,” Chief Executive Peter Sands wrote in a statement released on Thursday.


KEEPING LID ON COSTS


A rise in the number of out-of-work bankers meant Standard Chartered was able to maintain a lid on costs, with revenue growing faster than costs — a phenomenon known in financial industry jargon as “positive jaws”.


For much of 2010, StanChart was hit by ever-rising costs as an increasing number of banks and brokerages tried to expand in Asia. Since then, various minor players including Samsung Securities and KBW have begun pulling out.


The bank does not release specific numbers in its trading updates, which it keeps for its annual report that is typically released in late February. It singled out Malaysia, China and Indonesia as regions where income grew by at least 10 percent.


In Hong Kong, its biggest market, income grew at a high single-digit percentage, the bank said.


StanChart’s Hong Kong-listed shares are up 9 percent year-to-date, lagging the 20 percent rise on the Hang Seng Index.


Asset quality remained good, the bank said, with loan impairments within the wholesale bank expected to be below the levels seen in the first half of this year. For the consumer bank, loan impairment is expected to increase by at least 10 percent from the first half.


However, StanChart pointed to India and the Middle East as two markets where it was watchful for asset quality. Slowing growth in some emerging markets has raised concern that StanChart could be hit by a rise in bad loans.


The bank appointed a new global head of loan syndication in late November, naming Cristian Jonsson to replace Philip Cracknell, who is retiring in March.


To diversify away from its traditional lending business, the bank has been looking to expand to areas such as commodities, where it aims to double revenue in the next four years, it said on Tuesday.


(Editing by Alex Richardson)


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Male artists lead 2013 Grammy nominations












NASHVILLE, Tennessee (Reuters) – Male artists led the nominations announced on Wednesday for the 2013 Grammys, as fun., Frank Ocean, Mumford & Sons, Jay-Z, Kanye West and Dan Auerbach from The Black Keys landed six nods each for music’s biggest awards.


The nominations for New York-based indie-pop band fun. – made up of Nate Ruess, Andrew Dost and Jack Antonoff – included the four main categories for record, song and album of the year, and best new artist.












fun., which also performed at the Grammy nominations concert with Janelle Monae, said it felt good to be recognized and “took pride” in its live performances.


“Tonight, all I wanted to do was get up and really give it our all … receiving the nomination is amazing and a culmination of hard work the three of us have put into this band,” lead singer Ruess told reporters backstage.


The group scored a huge hit with its first single, “We Are Young,” and then followed that up with its successful album “Some Nights” and single of the same name.


Joining it in the album, record of the year and best new artist categories was hip hop artist Ocean.


The 25-year-old rapper-singer made waves earlier this year after revealing his first love was a man, a groundbreaking move in the hip hop industry, which has faced criticism in the past for being hostile toward gays.


His debut album, “Channel Orange” was a critical and commercial success, debuting at No. 2 on the Billboard 200 album chart in July.


Ocean and fun. will be competing with blues-rock group Alabama Shakes, country singer Hunter Hayes and folk-rockers The Lumineers for the coveted best new artist title.


While young male artists made up a large portion of nominees in key categories, noticeably absent was 18-year-old Canadian singer Justin Bieber, one of 2012′s biggest pop music stars with chart-topping album “Believe” and singles such as “Boyfriend.”


The winners will be announced at the televised awards show in Los Angeles on February 10.


AFTER ADELE, MALE ARTISTS LEAD


After British singer Adele dominated the previous Grammy Awards with her juggernaut album “21,” male artists took the lead in the album of the year category, where Ocean and fun. are competing with The Black Keys, Mumford & Sons and Jack White.


British folk band Mumford & Sons, which scored six nominations both in 2011 and 2012 for its debut album, “Sigh No More,” landed six more nominations on Wednesday for its chart-topping sophomore album, “Babel,” which is the second biggest-selling album in the United States this year.


Ohio rock duo The Black Keys, formed by frontman Auerbach and drummer Patrick Carney, landed five nominations, while Auerbach also notched a non-classical producer of the year nomination for his work on four albums.


Blues-rocker Jack White, the former frontman of The White Stripes, picked up three nods for his chart-topping debut solo album “Blunderbuss.”


Rappers Jay-Z and Kanye West continued to pick up nods for their 2011 album, “Watch The Throne,” including best rap performance for “N****s in Paris.” Jay-Z also landed nods for collaborating on songs with Young Jeezy and Rihanna, while West scored multiple nominations for his song “Mercy.”


Kelly Clarkson was one of the few leading female nominees, picking up three nominations, including record of the year and best pop vocal album.


R&B singer Rihanna also landed three nods, including best solo pop performance for “Where Have You Been.”


Record of the year nominees saw an assortment of rock, pop and hip hop nominees, with Clarkson’s “Stronger” competing with The Black Keys‘ “Lonely Boy,” fun.’s “We Are Young,” Australian artist Gotye’s heartbreak hit “Somebody That I Used To Know,” Ocean’s “Thinkin Bout You,” and Taylor Swift’s “We Are Never Ever Getting Back Together.”


To be eligible for nominations this year, artists had to release their music between October 1, 2011, and September 30, 2012.


Adele, who swept the awards in February with six accolades including the top three, landed only one nomination this year for best pop solo performance, as she did not release any music in the eligibility time frame.


The nominations for the top awards and main categories were announced during an hour-long televised concert in Nashville for the first time, co-hosted by country-pop artist Swift and veteran Grammy host, rapper-actor LL Cool J.


Adding a twist to the announcements, Hayes sang the nominees for best pop album, a tight contest between Maroon 5, Clarkson, Pink, fun. and Florence and the Machine. Hayes picked up two nods for best new artist and best country vocal performance.


British rock legends The Who will receive the Grammy Lifetime Achievement Award in February.


(Writing by Piya Sinha-Roy; Editing by Peter Cooney and Lisa Shumaker)


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